Hans-Uwe Simon Selected Research

Hypereosinophilic Syndrome (Loeffler Endocarditis)

12/2016	RhoH is a negative regulator of eosinophilopoiesis.
1/2011	Eosinophil extracellular DNA traps in skin diseases.
12/2009	Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
4/2008	Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia.
3/2008	Treatment of patients with the hypereosinophilic syndrome with mepolizumab.
8/2007	Novel approaches to therapy of hypereosinophilic syndromes.
7/2006	cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis.
6/2006	Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.
1/2005	Anti-interleukin-5 antibody therapy in eosinophilic diseases.
9/2002	High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome.

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Hans-Uwe Simon Research Topics

Disease

28	Neoplasms (Cancer) 11/2022 - 08/2003
19	Inflammation (Inflammations) 01/2021 - 03/2002
16	Eosinophilia 01/2021 - 09/2002
13	Eosinophilic Esophagitis 01/2021 - 07/2002
12	Asthma (Bronchial Asthma) 01/2021 - 07/2002
11	Atopic Dermatitis (Atopic Eczema) 12/2021 - 07/2002
11	Hypereosinophilic Syndrome (Loeffler Endocarditis) 12/2016 - 07/2002
10	Melanoma (Melanoma, Malignant) 01/2021 - 01/2005
6	Autoimmune Diseases (Autoimmune Disease) 11/2020 - 12/2006
4	Infections 11/2022 - 10/2011
4	Rheumatoid Arthritis 11/2020 - 08/2005
4	Hypersensitivity (Allergy) 01/2016 - 11/2002
3	Sepsis (Septicemia) 11/2020 - 09/2008
3	Bullous Pemphigoid (Pemphigoid) 01/2020 - 01/2011
3	Septic Shock (Toxic Shock Syndrome) 10/2009 - 08/2005
2	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2021 - 07/2007
2	COVID-19 11/2021 - 01/2020
2	Nasal Polyps (Nasal Polyp) 01/2021 - 07/2002
2	Crohn Disease (Crohn's Disease) 01/2021 - 11/2020
2	Nevus (Nevi) 01/2021 - 09/2013
2	Fibrosis (Cirrhosis) 10/2020 - 10/2020
2	Lung Diseases (Lung Disease) 01/2020 - 08/2006
2	Neoplasm Metastasis (Metastasis) 01/2020 - 10/2013
2	Hypoxia (Hypoxemia) 01/2019 - 10/2013
2	Allergic Rhinitis 01/2019 - 06/2002
2	Necrosis 01/2018 - 06/2011
2	Skin Diseases (Skin Disease) 12/2017 - 01/2011
2	Communicable Diseases (Infectious Diseases) 09/2015 - 12/2003
2	Carcinogenesis 04/2015 - 02/2015
2	Wells syndrome 01/2011 - 04/2003
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 06/2008 - 12/2005
2	Churg-Strauss Syndrome (Allergic Angiitis) 04/2007 - 06/2006
2	Parasitic Diseases (Parasitic Disease) 12/2005 - 07/2002
1	Tuberculosis (Tuberculoses) 11/2022
1	Thrombosis (Thrombus) 11/2022
1	Rheumatic Diseases (Rheumatism) 11/2022
1	Insulin Resistance 01/2021
1	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 01/2021
1	Rhinosinusitis 01/2021
1	Osteoporosis 12/2020
1	Heart Failure 10/2020
1	Fatty Liver 10/2020

Drug/Important Bio-Agent (IBA)

15	CytokinesIBA 01/2021 - 07/2002
13	Proteins (Proteins, Gene)FDA Link 12/2021 - 02/2004
8	Pharmaceutical PreparationsIBA 01/2020 - 01/2009
6	Intravenous Immunoglobulins (IVIG)FDA Link 11/2020 - 12/2006
6	Monoclonal AntibodiesIBA 01/2019 - 07/2007
6	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 09/2008
5	Interleukin-5 (Interleukin 5)IBA 01/2021 - 03/2002
5	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2020 - 11/2002
5	LigandsIBA 01/2019 - 01/2005
5	SurvivinIBA 01/2013 - 05/2004
4	CaspasesIBA 10/2020 - 05/2005
4	mepolizumabIBA 01/2020 - 03/2008
4	AllergensIBA 12/2017 - 01/2008
3	GlucocorticoidsIBA 11/2022 - 10/2013
3	VaccinesIBA 11/2021 - 09/2015
3	Immunoglobulin G (IgG)IBA 11/2020 - 08/2008
3	Biomarkers (Surrogate Marker)IBA 10/2020 - 11/2010
3	Caspase 8 (Caspase-8)IBA 01/2020 - 03/2008
3	AntigensIBA 11/2019 - 09/2015
3	Sialic Acid Binding Immunoglobulin-like LectinsIBA 01/2019 - 08/2011
3	Interleukin-5 Receptors (Interleukin 5 Receptor)IBA 01/2019 - 01/2009
3	LeptinIBA 01/2019 - 06/2005
3	Death-Associated Protein KinasesIBA 01/2016 - 06/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2008 - 11/2002
2	Biological ProductsIBA 11/2022 - 01/2021
2	Immunoglobulin A (IgA)IBA 11/2020 - 12/2014
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 01/2018
2	Interleukin-15 (Interleukin 15)IBA 01/2020 - 08/2017
2	InterleukinsIBA 01/2020 - 12/2003
2	Autophagy-Related ProteinsIBA 01/2020 - 01/2018
2	benralizumabIBA 01/2019 - 01/2019
2	SteroidsIBA 01/2019 - 01/2019
2	Phosphotransferases (Kinase)IBA 01/2018 - 01/2016
2	ParaffinIBA 01/2018 - 01/2011
2	AutoantibodiesIBA 12/2017 - 04/2007
2	Autophagy-Related Protein 5IBA 02/2015 - 09/2013
2	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2011 - 03/2008
2	Budesonide (Pulmicort)FDA LinkGeneric 05/2011 - 11/2010
2	Eosinophil Cationic ProteinIBA 01/2011 - 04/2003
2	Death Domain ReceptorsIBA 07/2010 - 05/2010
2	Immunoglobulin E (IgE)IBA 01/2008 - 05/2005
2	Fas Ligand Protein (Fas Ligand)IBA 06/2006 - 01/2005
2	Interleukin-13IBA 10/2003 - 07/2002
1	Antirheumatic Agents (DMARD)IBA 11/2022
1	Janus Kinase InhibitorsIBA 11/2022
1	Janus KinasesIBA 11/2022
1	Methotrexate (Mexate)FDA LinkGeneric 11/2022
1	CathepsinsIBA 12/2021
1	dupilumabIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Keratin-18 (Keratin 18)IBA 10/2020
1	Plasminogen Activators (Plasminogen Activator)IBA 10/2020

Therapy/Procedure

25	Therapeutics 11/2021 - 01/2005
4	Drug Therapy (Chemotherapy) 11/2022 - 01/2009
4	Immunotherapy 01/2019 - 08/2011
3	Ligation 01/2020 - 09/2008
2	Precision Medicine 01/2020 - 01/2016
2	Radiotherapy 10/2013 - 01/2013